Non-Genetic Risk Stratification Model of Allopurinol induced Severe Cutaneous Adverse drug Reactions Prognostic Score (NoG-ASCAR Score)

Probability (Model 2): 1.83%

Moderate non-genetic risk of allopurinol induced severe cutaneous adverse drug reactions. HLA-B*58:01 genetic testing is required before allopurinol prescription. However, if the testing is negative result, monitoring of severe cutaneous adverse drug reactions is recommended after starting allopurinol.

Model 1a

Probability by model 1a=e1.295327×female0.0140479×age0.0171667×mdrd0.4593728×diuretic4.044362e1.295327×female0.0140479×age0.0171667×mdrd0.4593728×diuretic4.044362+1

Model 1b

Probability by model 1b=e0.8150534×female+0.0162546×age0.0060181×mdrd+0.1772109×sua+2.020398×diuretic8.196047e0.8150534×female+0.0162546×age0.0060181×mdrd+0.1772109×sua+2.020398×diuretic8.196047+1

Model 2

Probability by model 2=e1.191076×female+0.0071005×age0.0216015×mdrd+0.0145356×allo_dose+0.9388491×diuretic7.109544e1.191076×female+0.0071005×age0.0216015×mdrd+0.0145356×allo_dose+0.9388491×diuretic7.109544+1